Tylenol (acetaminophen) or Advil (ibuprofen) are known medications often used when facing fever, headache, or body aches. Though both relieve pain and reduce fever, they act differently in the body. How They Work Tylenol (acetaminophen) works on the brain’s pain and temperature centers. It’s great for reducing fever and easing general aches, like headaches or minor joint pains, however it doesn’t help with swelling. Advil (ibuprofen), on the other hand, is part of a group called NSAIDs. It not only reli...